Anticoagulant medication is used to slow down the blood clotting process.
Anticoagulants can be used to prevent a clot forming in the blood or to help treat existing clots.
Blood thinners...as they are commonly and incorrectly known do not dissolve existing blood clots though, another class of pharmaceutical drug called a Thrombolytic is required to assist with that process.
However, this class of drugs can help treat existing blood clots by decreasing their expansion...stops them 'growing' in size.
The most well known anticoagulant medication is probably Warfarin with Heparin a close second.
Anticoagulants are used in the treatment of:
Warfarin is an antagonist of vitamin K...Vitamin K being necessary for the production of certain blood clotting factors.The rate of production of blood factors and proteins which are responsible for the clotting process is dependant on vitamin K
A deficiency of Vitamin K produces an environment of increasing Anticoagulation.
K will clot...no K will not!
With respect to the name Coumadin, this is derived from Coumarin....a substance from which several anticoagulants are derived and which is present in a number of plants species.
It usually takes several days (up to five) for warfarin to take effect...this is called the lead in time...and the effect of that dose will last about five days...however patients on warfarin usually take daily doses to maintain stability and control of the anticoagulation process.
Possible side effects of Anticoagulant therapy may include:
you are on warfarin therapy then moderate exercise is fine...but contact sports that could cause physical injury are discouraged as controlling the bleeding from injury may be problematic and require medical assistance.
Heparin is sourced from the mucosal tissues of dead animals....particularly the intestinal tissue of pigs and the lung tissue of cows.
Heparin is also a polysaccharide - a substance containing several sugar molecules found naturally in many cells.
Heparin acts against three different clotting factors by preventing formation of...
and...decreasing the availability of...
Compared with warfarin, heparin does not dissolve blood clots but can help to prevent them form occurring and from getting larger if they are already present.
Low molecular weight Heparin:
This is a product that like heparin is used in the hospital or clinical setting...but unlike 'plain' Heparin it does not require regular monitoring in the patient for coagulation time...known as APTT or Activated Partial Thromboplastin Time. This is so because its levels in the blood are more predictable than that of 'plain 'Heparin.
Synthetic Pentasaccharide Inhibitors:
Heparin is a five sugar chemical structure. Some products that synthesize the natural heparin molecule such as Fondaparinux inhibit the action of a certain blood factor...factor Xa that is critical to the coagulation process.
Direct Thrombin Inhibitors:
Bivalirudin, trade name Angiomax is another class of anticoagulant drug. It acts as a direct thrombin inhibitor.
Interestingly, Bivilirudin is a synthetic of the naturally occurring Hirudin found in the saliva of the medicinal leech Hirudo medicinalis. Huriden is an anticoagulant also.
Bivalirudin and Hirudin inhibit thrombin formation by binding to thrombin that is circulating in the blood and thrombin that is present in clots already formed.
Bivalirudin has a low complication rate because it can be well controlled. Bivilirudin is not the kind of drug that a patient takes at home. It is usually found in the clinical setting especially in the cardiac catheterization lab as it has been shown to help reduce the risk of Acute Ischemic Complications.
Acute Ischemic Complications can be present in an acute patient who has come to the emergency room in the process of having a heart attack or occur in someone undergoing a balloon angioplasty (PCI) or Coronary Artery Stent implantation...simply as a result of procedure complications.
every biological process and are involved
in every major disease".
Read more about what the
National Acadamy of Sciences
has to say about the importance of Glycans....also known as Glyconutrients, Carbohydrates,
Saccharides or simply as Sugars...
Download the Pdf NOW and read about
this for yourself
Click here to read
Importance of Glycans in
Health and Disease in your browser or
right-click to download it.